3 research outputs found
Human retinal oximetry using spectral imaging
The principal aim of the research described in this thesis was to develop a technique
of non-invasively measuring the oxygen saturation within the retinal vasculature of human
subjects (retinal oximetry). The evaluation of a hyperspectral fundus camera used to acquire
retinal images in different wavelengths of visible light, and the image analysis techniques
used to perform retinal oximetry are described.
Validation of the oximetry techniques was performed using an artificial eye
containing human blood of known oxygen saturation: the calculated oxygen saturation was
compared to the gold standard measurement. The mean differences between the calculated
and measured oxygen saturations were small.
Hyperspectral imaging/oximetry of normal subjects was performed to characterize the
oximetric features of the retinal vasculature. The mean oxygen saturation (± SD) of the
temporal retinal arterioles and venules were 110.8% (± 11.8%) and 27.7% (± 3.2%)
respectively.
The application of the retinal oximetry technique was explored in patients with retinal
arterial and venous occlusion to determine whether oximetric changes in the retinal
vasculature could be detected. Variation in measured oxygen saturation of the retinal
arterioles and venules respectively were apparent, and corresponded with angiographic
features of retinal capillary loss.
The techniques were applied to patients with asymmetrical primary open angle
glaucoma to determine whether oximetric changes could be detected. The mean oxygen
saturation of the temporal retinal venules were significantly higher [44.8% (± 24.2%)] in the
more advanced glaucomatous eyes compared to normal subjects. Hyperoxia of the retinal
venules suggests reduced oxygen consumption as a consequence of inner retinal dysfunction
in glaucoma. However, because of the small sample size, further research on a larger
population of subjects is required to support this finding.
Hyperspectral imaging could be used to detect oximetric abnormalities in the retinal
vasculature in patients with retinovascular occlusion and glaucoma
Lagrangian Statistics and Temporal Intermittency in a Shell Model of Turbulence
We study the statistics of single particle Lagrangian velocity in a shell
model of turbulence. We show that the small scale velocity fluctuations are
intermittent, with scaling exponents connected to the Eulerian structure
function scaling exponents. The observed reduced scaling range is interpreted
as a manifestation of the intermediate dissipative range, as it disappears in a
Gaussian model of turbulence.Comment: 4 pages, 5 figure